dsRNA induces IL-33 promoter activity through TLR3-EGFR-IRF3 pathway in normal human epidermal keratinocytes

J Dermatol Sci. 2019 Dec;96(3):178-180. doi: 10.1016/j.jdermsci.2019.11.002. Epub 2019 Nov 19.

Authors

Meijuan Jin¹, Mayumi Komine², Hidetoshi Tsuda¹, Tomoyuki Oshio¹, Mamitaro Ohtsuki¹

Affiliations

¹ Department of Dermatology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan.
² Department of Dermatology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan. Electronic address: [email protected].

PMID: 31810599
DOI: 10.1016/j.jdermsci.2019.11.002

No abstract available

Publication types

Letter

MeSH terms

ErbB Receptors / metabolism
Gene Expression Regulation
Humans
Interferon Regulatory Factor-3 / metabolism
Interleukin-33 / metabolism*
Keratinocytes / metabolism*
Promoter Regions, Genetic
Signal Transduction
Toll-Like Receptor 3 / metabolism

Substances

IL33 protein, human
IRF3 protein, human
Interferon Regulatory Factor-3
Interleukin-33
TLR3 protein, human
Toll-Like Receptor 3
EGFR protein, human
ErbB Receptors