Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men

Monika Sarkar; Katherine Yates; Ayako Suzuki; Joel Lavine; Ryan Gill; Toni Ziegler; Norah Terrault; Sandeep Dhindsa

doi:10.1016/j.cgh.2019.11.053

Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men

Clin Gastroenterol Hepatol. 2021 Feb;19(2):400-402.e2. doi: 10.1016/j.cgh.2019.11.053. Epub 2019 Dec 5.

Authors

Monika Sarkar¹, Katherine Yates², Ayako Suzuki³, Joel Lavine⁴, Ryan Gill⁵, Toni Ziegler⁶, Norah Terrault⁷, Sandeep Dhindsa⁸

Affiliations

¹ Division of Gastroenterology and Hepatology, University of California, San Francisco, San Francisco, California. Electronic address: [email protected].
² Department of Biostats and Epidemiology, Johns Hopkins University, Baltimore, Maryland.
³ Division of Gastroenterology and Hepatology, Duke University, Durham, North Carolina.
⁴ Division of Pediatric Gastroenterology and Hepatology, Columbia University, New York, New York.
⁵ Department of Pathology, University of California, San Francisco, San Francisco, California.
⁶ National Primate Research Center, University of Wisconsin, Madison, Wisconsin.
⁷ Division of Gastroenterology and Hepatology, University of California, San Francisco, San Francisco, California; Division of Gastroenterology and Hepatology, University of Southern California, Los Angeles, California.
⁸ Division of Endocrinology and Metabolism, Saint Louis University, Saint Louis, Missouri.

Abstract

With rising prevalence of obesity and diabetes, nonalcoholic fatty liver disease (NAFLD) is now a leading cause of chronic liver disease. One-third of obese or diabetic men have subnormal free and bioavailable testosterone concentrations.¹ Several studies have further shown low testosterone to be associated with imaging-confirmed NAFLD in men,² although it is unknown whether low testosterone confers increased risk of more clinically relevant manifestations of NAFLD, including nonalcoholic steatohepatitis (NASH) and NASH fibrosis. We therefore aimed to evaluate the association of testosterone with histologic features of NAFLD among a representative cohort of men from the multicenter NASH Clinical Research Network (NASH CRN).

Publication types

Multicenter Study
Research Support, N.I.H., Extramural

MeSH terms

Fibrosis
Humans
Liver / pathology
Male
Non-alcoholic Fatty Liver Disease* / complications
Non-alcoholic Fatty Liver Disease* / pathology
Obesity / pathology
Testosterone

Substances

Testosterone

Abstract

Publication types

MeSH terms

Substances

Grants and funding