Effet indésirable rare d’un anti-IL-1RA

Rev Med Interne. 2020 May;41(5):343-345. doi: 10.1016/j.revmed.2019.11.008. Epub 2019 Dec 6.
[Article in French]

Abstract

Introduction: Anakinra is an anti-IL-1RA targeting IL-1β with a central role in the occurrence of auto-inflammatory diseases. Its use is not without risk.

Case report: We report a case of late onset auto-inflammatory syndrome treated with anti-IL-1RA whose progression was marked by deep isolated thrombocytopenia, rapidly regressive after discontinuation of anakinra.

Conclusion: Immuno-allergic thrombocytopenia to anakinra is a rare, but serious adverse event.

Keywords: Anakinra; Anti-IL-1RA; Auto-inflammatory syndrome; Drug-induced immune thrombocytopenia; IL-1; Syndrome auto-inflammatoire; Thrombocytopénie immunitaire d’origine médicamenteuse.

Publication types

  • Case Reports

MeSH terms

  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / pathology
  • Autoimmune Diseases / chemically induced
  • Autoimmune Diseases / diagnosis
  • Female
  • Humans
  • Inflammation / chemically induced
  • Inflammation / diagnosis
  • Interleukin 1 Receptor Antagonist Protein / adverse effects*
  • Middle Aged
  • Syndrome
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / diagnosis

Substances

  • Interleukin 1 Receptor Antagonist Protein