Cerebrospinal fluid neurofilament light chain is elevated in Niemann-Pick type C compared to psychiatric disorders and healthy controls and may be a marker of treatment response

Dhamidhu Eratne; Samantha M Loi; Qiao-Xin Li; Shiji Varghese; Amelia McGlade; Steven Collins; Colin L Masters; Dennis Velakoulis; Mark Walterfang

doi:10.1177/0004867419893431

Cerebrospinal fluid neurofilament light chain is elevated in Niemann-Pick type C compared to psychiatric disorders and healthy controls and may be a marker of treatment response

Aust N Z J Psychiatry. 2020 Jun;54(6):648-649. doi: 10.1177/0004867419893431. Epub 2019 Dec 11.

Authors

Dhamidhu Eratne^{1

2

3

4}, Samantha M Loi^{1

2

3}, Qiao-Xin Li⁴, Shiji Varghese⁴, Amelia McGlade⁴, Steven Collins^{4

5

6}, Colin L Masters^{4

7}, Dennis Velakoulis^{1

2

3}, Mark Walterfang^{1

2

3}

Affiliations

¹ Neuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, VIC, Australia.
² Neuropsychiatry Centre, University of Melbourne & NorthWestern Mental Health, Melbourne, VIC, Australia.
³ Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia.
⁴ National Dementia Diagnostics Laboratory, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
⁵ Department of Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia.
⁶ Australian National Creutzfeldt-Jakob Disease Registry, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
⁷ Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.

PMID: 31823653
DOI: 10.1177/0004867419893431

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Biomarkers / cerebrospinal fluid
Case-Control Studies
Female
Humans
Intermediate Filaments / chemistry*
Male
Mental Disorders / cerebrospinal fluid*
Middle Aged
Neurofilament Proteins / cerebrospinal fluid*
Niemann-Pick Disease, Type C / cerebrospinal fluid*
Niemann-Pick Disease, Type C / therapy*
Treatment Outcome

Substances

Biomarkers
Neurofilament Proteins