Short Communication: Interaction of Nerve Growth Factor (NGF) and Vascular Endothelial Growth Factor (VEGF) in Healthy Individuals

Adrian Groh; Kirsten Jahn; Michael Gröschl; Thomas Hillemacher; Johannes Kornhuber; Stefan Bleich; Helge Frieling; Annemarie Heberlein

doi:10.1155/2019/7510315

Short Communication: Interaction of Nerve Growth Factor (NGF) and Vascular Endothelial Growth Factor (VEGF) in Healthy Individuals

Dis Markers. 2019 Nov 11:2019:7510315. doi: 10.1155/2019/7510315. eCollection 2019.

Authors

Adrian Groh¹, Kirsten Jahn¹, Michael Gröschl², Thomas Hillemacher^{1

3}, Johannes Kornhuber⁴, Stefan Bleich¹, Helge Frieling¹, Annemarie Heberlein¹

Affiliations

¹ Department of Psychiatry, Social Psychiatry and Psychotherapy, Center for Addiction Research, Medical School Hanover, Germany.
² Celerion Switzerland AG, Switzerland.
³ Paracelsus Medical University Nuremberg, Germany.
⁴ Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany.

Abstract

NGF and VEGF are known to be involved in different psychiatric diseases. In order to verify hints from basic research that both neurotrophines interact with each other, serum levels of NGF and VEGF were measured in a cohort of 33 healthy individuals and correlated. NGF level was 126.30 pg/mL (±155.43), and VEGF level was 57.28 pg/mL (±44.48). Both factors were significantly correlated, confirming their interaction and legitimising the usage of their respective ratio (0.8 (±0.42)) as a less varying additional marker in prospective studies.

MeSH terms

Adult
Cohort Studies
Female
Healthy Volunteers
Humans
Male
Nerve Growth Factor / metabolism*
Protein Interaction Domains and Motifs
Vascular Endothelial Growth Factor A / metabolism*

Substances

NGF protein, human
VEGFA protein, human
Vascular Endothelial Growth Factor A
Nerve Growth Factor