Abstract
We report the design, synthesis, immunological evaluation, and conformational analysis of new saponin variants as promising vaccine adjuvants. These studies have provided expedient synthetic access to streamlined adjuvant-active saponins and yielded molecular-level insights into saponin conformation that correlated with their in vivo adjuvant activities.
MeSH terms
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Adjuvants, Immunologic / chemical synthesis
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Adjuvants, Immunologic / pharmacology*
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Adjuvants, Immunologic / toxicity
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Animals
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Drug Design
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Female
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Immunity, Humoral / drug effects
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Mice, Inbred C57BL
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Molecular Conformation
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Molecular Dynamics Simulation
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Ovalbumin / immunology
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Saponins / chemical synthesis
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Saponins / pharmacology*
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Saponins / toxicity
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Structure-Activity Relationship
Substances
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Adjuvants, Immunologic
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Saponins
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saponin QA-21V1
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Ovalbumin