Role of bioclimate conditions on cerebral aneurysm rupture in the Brittany region of France

Neurochirurgie. 2020 Feb;66(1):9-15. doi: 10.1016/j.neuchi.2019.11.001. Epub 2019 Dec 10.

Abstract

Introduction: Subarachnoid hemorrhage (SAH) from intracranial aneurysm rupture is an unpredictable event responsible for significant morbidity and mortality. Despite inconsistencies, some studies suggest a potential role of climate conditions in SAH onset. The purpose of this study was to determine the impact of climatic and lunar factors on onset of SAH in an oceanic climate such as that of Brittany, France.

Methods: All adults with SAH admitted to the neurosurgery department and intensive care unit of the University Hospital of Rennes (France) between January 1st, 2011 and December 31st, 2012 were included. Meteorological variables, their variations, lunar phases and tidal coefficients were compared between days with and without SAH.

Results: We retrospectively included 295 patients with SAH. Mean minimum temperature was significantly lower during days with SAH (7.7±4.7°C versus 8.3±4.6°C; P=0.039); temperature variation between 2 successive days was significantly greater for days with SAH (8.6±4.1°C versus 7.9±3.8°C; P<0.01). Multivariate analysis showed that a 2-day temperature drop greater than or equal to 8°C was associated with 35% increased risk of SAH (odds ratio 1.35 [1.03-1.77]). There were no significant effects of other meteorological variables, lunar phase or tidal coefficient on SAH occurrence.

Conclusion: Low temperature and sudden temperature drop were associated with increased occurrence of SAH in Brittany, France.

Keywords: Cerebral aneurysm; Climate conditions; Meteorological variables; Subarachnoid hemorrhage.

MeSH terms

  • Adult
  • Aged
  • Air Pressure
  • Aneurysm, Ruptured / epidemiology*
  • Climate*
  • Cold Temperature
  • Critical Care / statistics & numerical data
  • Female
  • France / epidemiology
  • Humans
  • Intracranial Aneurysm / complications
  • Intracranial Aneurysm / epidemiology*
  • Male
  • Middle Aged
  • Moon
  • Oceans and Seas
  • Retrospective Studies
  • Seasons
  • Temperature
  • Weather