Arsenic and gallbladder cancer risk: Mendelian randomization analysis of European prospective data

Carol Barahona Ponce; Dominique Scherer; Felix Boekstegers; Valentina Garate-Calderon; Mazda Jenab; Krasimira Aleksandrova; Verena Katzke; Elisabete Weiderpass; Catalina Bonet; Tahereh Moradi; Krista Fischer; Willem Bossers; Hermann Brenner; Ben Schöttker; Bernd Holleczek; Kristian Hveem; Niina Eklund; Uwe Völker; Melanie Waldenberger; Justo Lorenzo Bermejo

doi:10.1002/ijc.32837

Arsenic and gallbladder cancer risk: Mendelian randomization analysis of European prospective data

Int J Cancer. 2020 May 1;146(9):2648-2650. doi: 10.1002/ijc.32837. Epub 2019 Dec 31.

Authors

Carol Barahona Ponce^{1

2}, Dominique Scherer¹, Felix Boekstegers¹, Valentina Garate-Calderon^{1

2}, Mazda Jenab³, Krasimira Aleksandrova^{4

5}, Verena Katzke⁶, Elisabete Weiderpass³, Catalina Bonet⁷, Tahereh Moradi⁸, Krista Fischer⁹, Willem Bossers¹⁰, Hermann Brenner^{11

12

13}, Ben Schöttker¹¹, Bernd Holleczek¹⁴, Kristian Hveem^{15

16}, Niina Eklund¹⁷, Uwe Völker¹⁸, Melanie Waldenberger¹⁹, Justo Lorenzo Bermejo¹

Affiliations

¹ Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
² Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago, Chile.
³ International Agency for Research on Cancer, World Health Organization, Lyon, France.
⁴ Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
⁵ Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.
⁶ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁷ Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain.
⁸ Division of Epidemiology, Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
⁹ Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
¹⁰ Lifelines, Groningen, Netherlands.
¹¹ Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹² Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
¹³ German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁴ Saarland Cancer Registry, Saarbrücken, Germany.
¹⁵ The Nord-Trøndelag Health (HUNT) Research Centre, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
¹⁶ K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
¹⁷ Genomiikka ja Biomarkkerit, National Institute for Health and Welfare (THL), Helsinki, Finland.
¹⁸ Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Universitätsmedizin Greifswald, Germany.
¹⁹ Research Unit of Molecular Epidemiology and Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

PMID: 31846055
DOI: 10.1002/ijc.32837

No abstract available

Keywords: Mendelian randomization; arsenic; gallbladder cancer.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Arsenic*
Gallbladder Neoplasms*
Gallstones*
Humans
Mendelian Randomization Analysis
Metals
Polymorphism, Single Nucleotide
Prospective Studies
Risk Factors

Substances

Metals
Arsenic

Grants and funding

001/WHO_/World Health Organization/International