A Germline Mutation in the C2 Domain of PLCγ2 Associated with Gain-of-Function Expands the Phenotype for PLCG2-Related Diseases

Affiliations

• ¹ University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA.
• ² Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, Canada.
• ³ Department of Pediatrics, BC Children's Hospital Research Institute, Vancouver, Canada.
• ⁴ Department of Pediatrics, Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
• ⁵ Division of Pediatric Hematology/Oncology, Department of Pediatrics, Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
• ⁶ Division of Pediatric Genetics, Metabolism & Genomic Medicine, Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
• ⁷ Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
• ⁸ Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, MI, USA.
• ⁹ Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
• ¹⁰ Division of Clinical Immunology & Allergy, Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, Canada.
• ¹¹ Division of Pediatric Hematology/Oncology and Bone Marrow Transplant, Department of Pediatrics, BC Children's Hospital, University of British Columbia, 4480 Oak Street, Vancouver, Canada.
• ¹² Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, Canada. [email protected].
• ¹³ Division of Pediatric Hematology/Oncology and Bone Marrow Transplant, Department of Pediatrics, BC Children's Hospital, University of British Columbia, 4480 Oak Street, Vancouver, Canada. [email protected].