Krüppel-like factors in breast cancer: Function, regulation and clinical relevance

Jianping Zhang; Guangliang Li; Lifeng Feng; Haiqi Lu; Xian Wang

doi:10.1016/j.biopha.2019.109778

Krüppel-like factors in breast cancer: Function, regulation and clinical relevance

Biomed Pharmacother. 2020 Mar:123:109778. doi: 10.1016/j.biopha.2019.109778. Epub 2019 Dec 17.

Authors

Jianping Zhang¹, Guangliang Li², Lifeng Feng³, Haiqi Lu⁴, Xian Wang⁵

Affiliations

¹ Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China; Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China.
² Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
³ Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China.
⁴ Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China; Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China. Electronic address: [email protected].
⁵ Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China; Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China. Electronic address: [email protected].

PMID: 31855735
DOI: 10.1016/j.biopha.2019.109778

Abstract

Breast cancer has accounted for the leading cause of cancer-related mortality among women worldwide. Although the progress in its diagnosis and treatment has come at a remarkable pace during the past several decades, there are still a wide array of problems regarding its progression, metastasis and treatment resistance that have not yet been fully clarified. Recently, an increasing number of studies have revealed that some members of Krüppel-like factors(KLFs) are significantly associated with cell proliferation, apoptosis, metastasis, cancer stem cell regulation and prognostic and predictive value for patients in breast cancer, indicating their promising prognostic and predictive potential for breast cancer survival and outcome. In this review, we will summarize our current knowledge of the functions, regulations and clinical relevance of KLFs in breast cancer.

Keywords: Breast cancer; Clinical relevance; Function; Krüppel-like factors (KLFs); Regulation.

Publication types

Review

MeSH terms

Apoptosis
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology
Drug Resistance, Neoplasm
Female
Humans
Kruppel-Like Transcription Factors / chemistry
Kruppel-Like Transcription Factors / metabolism*
Neoplasm Metastasis
Phylogeny

Substances

Kruppel-Like Transcription Factors