Local delivery of corticosteroids in clinical ophthalmology: A review

Adrian T Fung; Tuan Tran; Lyndell L Lim; Chameen Samarawickrama; Jennifer Arnold; Mark Gillies; Caroline Catt; Logan Mitchell; Andrew Symons; Robert Buttery; Lisa Cottee; Krishna Tumuluri; Paul Beaumont

doi:10.1111/ceo.13702

Local delivery of corticosteroids in clinical ophthalmology: A review

Clin Exp Ophthalmol. 2020 Apr;48(3):366-401. doi: 10.1111/ceo.13702. Epub 2020 Jan 22.

Authors

Adrian T Fung^{1

2

3}, Tuan Tran³, Lyndell L Lim^{4

5

6}, Chameen Samarawickrama^{1

3

7}, Jennifer Arnold⁸, Mark Gillies³, Caroline Catt^{3

9}, Logan Mitchell¹⁰, Andrew Symons¹¹, Robert Buttery¹², Lisa Cottee¹³, Krishna Tumuluri^{1

2

3}, Paul Beaumont¹³

Affiliations

¹ Westmead Clinical School, Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, New South Wales, Australia.
² Department of Ophthalmology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
³ Save Sight Institute, Central Clinical School, Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, New South Wales, Australia.
⁴ Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
⁵ Centre for Eye Research Australia, Melbourne, Victoria, Australia.
⁶ University of Melbourne, Melbourne, Victoria, Australia.
⁷ Liverpool Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
⁸ Marsden Eye Specialists, Sydney, New South Wales, Australia.
⁹ Children's Hospital Westmead, Westmead, New South Wales, Australia.
¹⁰ University of Otago, Dunedin, New Zealand.
¹¹ Royal Melbourne Hospital, Melbourne, Victoria, Australia.
¹² Melbourne Retina Associates, Melbourne, Victoria, Australia.
¹³ Eye Doctors Mona Vale, Sydney, New South Wales, Australia.

Abstract

Locally administered steroids have a long history in ophthalmology for the treatment of inflammatory conditions. Anterior segment conditions tend to be treated with topical steroids whilst posterior segment conditions generally require periocular, intravitreal or systemic administration for penetration. Over recent decades, the clinical applications of periocular steroid delivery have expanded to a wide range of conditions including macular oedema from retino-vascular conditions. Formulations have been developed with the aim to provide practical, targeted, longer-term and more efficacious therapy whilst minimizing side effects. Herein, we provide a comprehensive overview of the types of periocular steroid delivery, their clinical applications in ophthalmology and their side effects.

Keywords: Fluocinolone acetonide; corticosteroid; dexamethasone; prednisolone acetate; triamcinolone acetonide.

Publication types

Review

MeSH terms

Adrenal Cortex Hormones
Glucocorticoids* / therapeutic use
Humans
Macular Edema*
Ophthalmology*

Substances

Adrenal Cortex Hormones
Glucocorticoids