Abstract
Members of four cell guidance molecule families (the netrins, slits, ephrins and semaphorins) interact with their cognate cell surface receptors to guide cells during development and maintain tissue homeostasis. Integrated structure and cell-based analyses are providing insight into the mechanisms by which these signalling systems can deliver myriad outcomes that require exquisite accuracy in timing and location. Here we review recent advances in our understanding of the roles of oligomeric states, auto-inhibition, signalling assembly size and composition in cell guidance cue function.
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Biomarkers
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Cell Adhesion Molecules / chemistry
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Cell Adhesion Molecules / metabolism
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Ephrins / metabolism
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Humans
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Ligands*
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Macromolecular Substances / chemistry*
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Macromolecular Substances / metabolism*
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / metabolism
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Protein Binding
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Protein Interaction Domains and Motifs
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Protein Multimerization
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Receptors, Cell Surface / chemistry*
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Receptors, Cell Surface / metabolism*
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Semaphorins / chemistry
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Semaphorins / metabolism
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Signal Transduction*
Substances
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Biomarkers
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Cell Adhesion Molecules
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Ephrins
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Ligands
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Macromolecular Substances
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Nerve Tissue Proteins
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Receptors, Cell Surface
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Semaphorins
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plexin