Immune-neuroendocrine and metabolic disorders in human and experimental T. cruzi infection: New clues for understanding Chagas disease pathology

Florencia B González; Silvina R Villar; M Florencia Pacini; Oscar A Bottasso; Ana R Pérez

doi:10.1016/j.bbadis.2019.165642

Immune-neuroendocrine and metabolic disorders in human and experimental T. cruzi infection: New clues for understanding Chagas disease pathology

Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165642. doi: 10.1016/j.bbadis.2019.165642. Epub 2019 Dec 19.

Authors

Florencia B González¹, Silvina R Villar¹, M Florencia Pacini¹, Oscar A Bottasso¹, Ana R Pérez²

Affiliations

¹ Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentine.
² Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentine. Electronic address: [email protected].

PMID: 31866417
DOI: 10.1016/j.bbadis.2019.165642

Abstract

Studies in mice undergoing acute Trypanosoma cruzi infection and patients with Chagas disease, led to identify several immune-neuroendocrine disturbances and metabolic disorders. Here, we review relevant findings concerning such abnormalities and discuss their possible influence on disease physiopathology.

Keywords: Adipose tissue; Chagas disease; Glucocorticoids; Hypothalamus-pituitary-adrenal axis; IL-1 beta; PPAR-γ.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chagas Disease / immunology*
Chagas Disease / parasitology
Humans
Metabolic Diseases / immunology*
Metabolic Diseases / parasitology
Neuroendocrine Cells / immunology*
Neuroendocrine Cells / parasitology
Trypanosoma cruzi / immunology*