Two new hydroperoxy steroids from the South China Sea gorgonian Rumphella sp

Fang-Zhou Yin; Min Yang; Song-Wei Li; Meng-Jun Wu; Xia-Juan Huan; Ze-Hong Miu; Hong Wang; Yue-Wei Guo

doi:10.1016/j.steroids.2019.108558

Two new hydroperoxy steroids from the South China Sea gorgonian Rumphella sp

Steroids. 2020 Mar:155:108558. doi: 10.1016/j.steroids.2019.108558. Epub 2019 Dec 20.

Authors

Fang-Zhou Yin¹, Min Yang², Song-Wei Li², Meng-Jun Wu¹, Xia-Juan Huan², Ze-Hong Miu², Hong Wang³, Yue-Wei Guo⁴

Affiliations

¹ Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
³ Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address: [email protected].
⁴ Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China. Electronic address: [email protected].

PMID: 31866544
DOI: 10.1016/j.steroids.2019.108558

Abstract

Two new hydroperoxy steroids, namely, xidaosteroids A and B (1 and 2), along with five known related compounds 3-7, were isolated from the South China Sea gorgonian Rumphella sp.. Their structures were established by extensive spectroscopic analyses and comparison of the spectral data with those reported in the literature. In bioassay, compound 3 showed weak cytotoxicities against SNU-398 and Capan-1 cells.

Keywords: Cytotoxicities; Gorgonian; Hydroperoxy steroids; Rumphella sp..

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

A549 Cells
Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Proliferation / drug effects
China
Drug Screening Assays, Antitumor
HT29 Cells
Humans
Molecular Conformation
Stereoisomerism

Substances

Antineoplastic Agents