Abstract
A 12-kg infant was given intravenous dexmedetomidine 0.2 µg kg-1 min-1 as an adjunct for general anesthesia. The 60-fold increase in dexmedetomidine infusion rate caused a biphasic response with initial hypertension followed by bradycardia and hypotension requiring inotropic support. No postoperative or long-term sequelae were noted. Dexmedetomidine infusion is usually delivered as µg kg-1 h-1 .
Keywords:
adverse effect; medication error; pharmacodynamics; pharmacokinetics.
© 2019 John Wiley & Sons Ltd.
MeSH terms
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Adrenergic alpha-Agonists / therapeutic use
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Blood Pressure / drug effects
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Crystalloid Solutions / therapeutic use
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Dexmedetomidine / administration & dosage*
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Dexmedetomidine / adverse effects
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Drug Overdose / drug therapy
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Drug Overdose / etiology*
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Epinephrine / therapeutic use
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Equipment Failure*
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Heart Rate / drug effects
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Humans
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Hypnotics and Sedatives / administration & dosage*
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Hypnotics and Sedatives / adverse effects
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Infant
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Infusion Pumps / adverse effects*
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Male
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Norepinephrine / therapeutic use
Substances
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Adrenergic alpha-Agonists
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Crystalloid Solutions
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Hypnotics and Sedatives
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Dexmedetomidine
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Norepinephrine
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Epinephrine