A Novel Lineage of Ceftriaxone-resistant Salmonella Typhi From India That Is Closely Related to XDR S. Typhi Found in Pakistan

Ranjit Sah; Suzanne Donovan; Helena M B Seth-Smith; Guido Bloemberg; Daniel Wüthrich; Roger Stephan; Sushila Kataria; Mahadevan Kumar; Sonam Singla; Vikas Deswal; Amarjeet Kaur; Andreas Neumayr; Vladimira Hinic; Adrian Egli; Esther Kuenzli

doi:10.1093/cid/ciz1204

A Novel Lineage of Ceftriaxone-resistant Salmonella Typhi From India That Is Closely Related to XDR S. Typhi Found in Pakistan

Clin Infect Dis. 2020 Aug 22;71(5):1327-1330. doi: 10.1093/cid/ciz1204.

Authors

Ranjit Sah^{1

2}, Suzanne Donovan³, Helena M B Seth-Smith^{4

5

6}, Guido Bloemberg⁷, Daniel Wüthrich^{4

5

6}, Roger Stephan⁷, Sushila Kataria¹, Mahadevan Kumar¹, Sonam Singla¹, Vikas Deswal¹, Amarjeet Kaur¹, Andreas Neumayr^{8

9}, Vladimira Hinic^{4

5}, Adrian Egli^{4

5}, Esther Kuenzli^{8

9

10}

Affiliations

¹ Medanta The Medicity, Gurgaon, Haryana, India.
² Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
³ UCLA Medical Center, Los Angeles, California, USA.
⁴ Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.
⁵ Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland.
⁶ Swiss Institute of Bioinformatics, Basel, Switzerland.
⁷ National Reference Center for Enteropathogenic Bacteria and Listeria, Institute for Food Safety and Hygiene, University of Zurich, Zurich, Switzerland.
⁸ Swiss Tropical and Public Health Institute, Basel, Switzerland.
⁹ University of Basel, Basel, Switzerland.
¹⁰ Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

PMID: 31872221
DOI: 10.1093/cid/ciz1204

Abstract

Two MDR Salmonella Typhi isolates from India were found by whole genome sequencing to be closely related to the 2016 XDR S. Typhi outbreak strain from Pakistan. The Indian isolates have no chromosomal antimicrobial resistance cassette but carry the IncY plasmid p60006. Both isolates are susceptible to chloramphenicol, azithromycin, and carbapenems.

Keywords: Salmonella enterica serovar Typhi; ceftriaxone-resistance; extended-spectrum beta-lactamase (ESBL); plasmid-mediated quinolone resistance; whole genome sequencing.

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Ceftriaxone / pharmacology
Humans
India / epidemiology
Microbial Sensitivity Tests
Pakistan
Salmonella typhi* / genetics
Typhoid Fever* / drug therapy
Typhoid Fever* / epidemiology

Substances

Anti-Bacterial Agents
Ceftriaxone