Upregulated β-catenin signaling does not affect survival of pancreatic cancer cells during dual inhibition of GSK3B and HDAC

Pancreatology. 2020 Apr;20(3):558-561. doi: 10.1016/j.pan.2019.12.019. Epub 2019 Dec 24.

Authors

Kateryna Nesteruk¹, Ron Smits¹, Marco Bruno¹, Maikel P Peppelenbosch¹, Gwenny M Fuhler²

Affiliations

¹ Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, the Netherlands.
² Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, the Netherlands. Electronic address: [email protected].

PMID: 31882353
DOI: 10.1016/j.pan.2019.12.019

No abstract available

MeSH terms

Animals
Carcinoma, Pancreatic Ductal / pathology*
Cell Line, Tumor
Cell Survival / drug effects
Enzyme Inhibitors / pharmacology*
Gene Knockdown Techniques
Glycogen Synthase Kinase 3 beta / antagonists & inhibitors*
Histone Deacetylase Inhibitors / pharmacology*
Pyridines / pharmacology
Pyrimidines / pharmacology
Signal Transduction / drug effects*
Vorinostat / pharmacology
Wnt3A Protein / physiology
beta Catenin / genetics
beta Catenin / physiology*

Substances

Chir 99021
Enzyme Inhibitors
Histone Deacetylase Inhibitors
Pyridines
Pyrimidines
Wnt3A Protein
beta Catenin
Vorinostat
Glycogen Synthase Kinase 3 beta