A traditional Chinese medicine compound (Jian Er) for presbycusis in a mouse model: Reduction of apoptosis and protection of cochlear sensorineural cells and hearing

Yi Xuan; Dalian Ding; Weijun Xuan; Liyi Huang; Junbo Tang; Yulong Wei; Sizhong Chen; Michael R Hamblin

A traditional Chinese medicine compound (Jian Er) for presbycusis in a mouse model: Reduction of apoptosis and protection of cochlear sensorineural cells and hearing

Int J Herb Med. 2018 Nov-Dec;6(6):127-135.

Authors

Yi Xuan¹, Dalian Ding², Weijun Xuan³, Liyi Huang⁴, Junbo Tang⁵, Yulong Wei⁶, Sizhong Chen⁵, Michael R Hamblin⁴

Affiliations

¹ School of Engineering, Tufts University, Medford, MA, USA.
² Center for Hearing Deafness, the State University of New York at Buffalo, Buffalo, NY, USA.
³ Department of Otorhinolaryngology, Head and Neck Surgery, First Clinical Medical College and Hospital, Guangxi University of Chinese Medicine,Nanning, China.
⁴ Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
⁵ Department of Otorhinolaryngology, Head and Neck Surgery, First Clinical Medical College and Hospital, Guangxi University of Chinese Medicine, Nanning, China.
⁶ Department of Pharmaceutical Manufacturing, Ruikang Clinical Medical College, Guangxi University of Chinese Medicine, Nanning, China.

PMID: 31890893
PMCID: PMC6936738

Abstract

Age-related hearing loss (AHL) or presbycusis is steadily increasing due to the overall aging of the Chinese population. Traditional Chinese medicine (TCM) has long been used to prevent and treat deafness, but its effectiveness and mechanism of action are still uncertain. The present study tested a TCM preparation called "Jian Er" in a mouse model of prebycusis.

Keywords: C57BL/6J mice; auditory brainstem response; presbycusis; traditional Chinese medicine.

Abstract

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