Transmission of Clostridioides difficile infection (CDI) from patients less than 3 years of age in a pediatric oncology setting

Elizabeth Robilotti; Weihua Huang; N Esther Babady; Donald Chen; Mini Kamboj

doi:10.1017/ice.2019.360

Transmission of Clostridioides difficile infection (CDI) from patients less than 3 years of age in a pediatric oncology setting

Infect Control Hosp Epidemiol. 2020 Feb;41(2):233-236. doi: 10.1017/ice.2019.360.

Authors

Elizabeth Robilotti^{1

2}, Weihua Huang³, N Esther Babady^{1

4}, Donald Chen^{5

6}, Mini Kamboj^{1

2}

Affiliations

¹ Infectious Diseases, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
² Infection Control, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
³ Department of Pathology, New York Medical College, Valhalla, New York.
⁴ Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
⁵ Infection Prevention and Control Department, Westchester Medical Center, Valhalla, New York.
⁶ Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY, USA.

Abstract

Clostridioides difficile infection (CDI) is prevalent in pediatric oncology patients, but the transmission risk to peers is unknown. In 224 children with CDI, multilocus sequence typing (MLST) identified only 7 alleged transmission events (18%) originating from children <3 years old. None of these events were corroborated by WGS.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Child, Preschool
Clostridioides difficile / genetics
Clostridioides difficile / isolation & purification*
Clostridium Infections / epidemiology
Clostridium Infections / transmission*
Feces / microbiology
Humans
Infant
Infant, Newborn
Multilocus Sequence Typing
Neoplasms / therapy
Retrospective Studies
Ribotyping

Grants and funding

P30 CA008748/CA/NCI NIH HHS/United States