Abstract
Genome-wide polygenic scores (GPSs) integrate information from many common DNA variants into a single measure of inherited susceptibility, and can identify individuals who are at substantially elevated risk of developing important common diseases., For coronary artery disease, about 8% of the population can be identified who are at triple the normal risk based on genetic variation alone. Among these high polygenic score individuals, adherence to a healthy lifestyle or use of statins may offset increased inherited risk.,
Keywords:
coronary artery disease; epidemiology; genetics; genome.
Publication types
-
Letter
-
Randomized Controlled Trial
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Anticholesteremic Agents / therapeutic use
-
Benzodiazepines / therapeutic use*
-
Cardiovascular Diseases / drug therapy
-
Cardiovascular Diseases / epidemiology*
-
Cardiovascular Diseases / genetics
-
Cardiovascular Diseases / pathology
-
Case-Control Studies
-
Female
-
Genome, Human*
-
Genome-Wide Association Study*
-
Humans
-
Male
-
Multifactorial Inheritance*
-
Pharmacogenomic Testing
-
Risk Factors
-
Scotland / epidemiology
Substances
-
Anticholesteremic Agents
-
Benzodiazepines
-
evacetrapib