Multidimensional aspects of dyspnea in obese patients referred for cardiopulmonary exercise testing

Respir Physiol Neurobiol. 2020 Mar:274:103365. doi: 10.1016/j.resp.2019.103365. Epub 2019 Dec 30.

Abstract

We investigated the contributions of obesity on multidimensional aspects of dyspnea on exertion (DOE) in patients referred for clinical cardiopulmonary exercise testing (CPET). Ratings of perceived breathlessness (RPB, Borg scale 0-10) were collected in obese (BMI ≥ 30; n = 47) and nonobese (BMI ≤ 25; n = 27) patients during two (one lower: ∼30 W; and one higher: ∼50 W) 4-6 min constant load cycling bouts. Multidimensional dyspnea profiles (MDP) were collected in the final 26 obese and 14 nonobese patients of the sample. RPB was greater (p = 0.05) in obese (3.3 ± 2.2 vs 2.4 ± 1.4) at lower work rates, but similar at higher work rates (4.9 ± 2.2 vs 4.4 ± 1.8). MDP sensory score including unpleasantness was 4.3 ± 2.2 in obese vs 2.5 ± 1.9 in nonobese (p < 0.001). The affective score was 1.9 ± 2.2 vs 0.7 ± 0.7, respectively (p < 0.01). Breathing sensations including 'air hunger', 'effort', and 'breathing at lot' were greater (p < 0.05) in obese, making these patients more frustrated/angry (p < 0.05). Obesity should be considered as a potential independent influencing factor that provokes DOE and unpleasantness when assessing breathlessness during CPET.

Keywords: Breathlessness; Cardiorespiratory fitness; Exercise; Obesity; Shortness of breath.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anger / physiology
  • Bicycling / physiology
  • Body Mass Index
  • Dyspnea / diagnosis
  • Dyspnea / etiology
  • Dyspnea / physiopathology*
  • Dyspnea / psychology
  • Exercise Test*
  • Female
  • Frustration
  • Humans
  • Male
  • Middle Aged
  • Obesity / complications
  • Obesity / physiopathology*
  • Physical Exertion / physiology*
  • Pleasure / physiology
  • Retrospective Studies