AISF update on the diagnosis and management of adult-onset lysosomal storage diseases with hepatic involvement

Dig Liver Dis. 2020 Apr;52(4):359-367. doi: 10.1016/j.dld.2019.12.005. Epub 2020 Jan 2.

Abstract

Lysosomal storage diseases (LSDs) are a heterogeneous group of inherited disorders caused by loss-of-function mutations in genes encoding for lysosomal enzymes/proteins. The consequence is a progressive accumulation of substrates in these intracellular organelles, resulting in cellular and tissue damage. The overall incidence is about 1/8000 live births, but is likely underestimated. LSDs are chronic progressive multi-systemic disorders, generally presenting with visceromegaly, and involvement of the central nervous system, eyes, the skeleton, and the respiratory and cardiovascular systems. The age at onset and phenotypic expression are highly variable, according to the specific enzymatic defect and tissues involved, the residual activity, and the disease-causing genotype. Enzyme-replacement therapies and substrate-reduction therapies have recently become available, leading to the improvement in symptoms, disease progression and quality of life of affected individuals. Liver involvement and hepatosplenomegaly are frequent features of LSDs and a hallmark of adult-onset forms, frequently leading to medical attention. LSDs should therefore be considered in the differential diagnosis of liver disease with organomegaly. The present document will provide a short overview of adult-onset LSDs with hepatic involvement, highlighting the specificities and systemic manifestations of the ones most frequently encountered in clinical practice, which may hint at the correct diagnosis and the appropriate treatment.

Keywords: Acid sphingomyelinase deficiency; Cholesteryl ester storage disease; Enzyme replacement therapy; Gaucher disease; Liver fibrosis; Lysosomal acid lipase deficiency; Niemann–Pick disease; Substrate reduction therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Enzyme Replacement Therapy
  • Gaucher Disease
  • Humans
  • Italy
  • Lysosomal Storage Diseases / diagnosis*
  • Lysosomal Storage Diseases / drug therapy*
  • Lysosomal Storage Diseases / genetics
  • Lysosomal Storage Diseases / metabolism
  • Lysosomes / enzymology*
  • Niemann-Pick Diseases
  • Societies, Medical
  • Sphingomyelin Phosphodiesterase / deficiency
  • Wolman Disease

Substances

  • Sphingomyelin Phosphodiesterase