Central Nervous System Double Relapse of Acute Promyelocytic Leukemia and Acute Myelomonocytic Leukemia

Laura M Stanko; Vishnu Reddy; Fady M Mikhail; Nikolaos Papadantonakis

doi:10.1155/2019/4907352

Central Nervous System Double Relapse of Acute Promyelocytic Leukemia and Acute Myelomonocytic Leukemia

Case Rep Hematol. 2019 Dec 17:2019:4907352. doi: 10.1155/2019/4907352. eCollection 2019.

Authors

Laura M Stanko¹, Vishnu Reddy², Fady M Mikhail³, Nikolaos Papadantonakis⁴

Affiliations

¹ Internal Medicine Program, University of Alabama at Birmingham, Birmingham, AL, USA.
² Division of Anatomic Pathology and Neuropathology, University of Alabama at Birmingham, Birmingham, AL, USA.
³ Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
⁴ Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.

Abstract

Relapse of acute promyelocytic leukemia (APL) and non-M3-acute myeloid leukemia in the central nervous system (CNS) are rare events. Here, we describe a case of simultaneous relapses of APL and acute myelomonocytic leukemia on the CNS of a patient after allogeneic bone marrow transplant. This extremely unusual case highlights the difficulties that CNS leukemia relapses pose in the post-transplant setting.

Publication types

Case Reports