Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy

Yang Liu; Shiman Wu; Yanyan Liu; Hua Zhang; Meng Zhang; Zhongmin Tang; Yan Wang; Teng Gong; Zhenwei Yao; Xiangming Fang; Wenbo Bu

doi:10.1016/j.biomaterials.2020.119762

Cathodic protected Mn²⁺ by Na_xWO₃ nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy

Biomaterials. 2020 Mar:234:119762. doi: 10.1016/j.biomaterials.2020.119762. Epub 2020 Jan 8.

Authors

Yang Liu¹, Shiman Wu², Yanyan Liu³, Hua Zhang², Meng Zhang⁴, Zhongmin Tang⁴, Yan Wang⁵, Teng Gong¹, Zhenwei Yao², Xiangming Fang⁶, Wenbo Bu⁷

Affiliations

¹ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, College of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.
² Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
³ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, College of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China. Electronic address: [email protected].
⁴ State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
⁵ Department of Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, No.299 Qingyang Road, Liangxi District, Wuxi, 214023, China.
⁶ Department of Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, No.299 Qingyang Road, Liangxi District, Wuxi, 214023, China. Electronic address: [email protected].
⁷ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, College of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China; State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China. Electronic address: [email protected].

PMID: 31935593
DOI: 10.1016/j.biomaterials.2020.119762

Abstract

The stability and safety of magnetic resonance imaging (MRI) contrast agents (CAs) are crucial for accurate diagnosis and real-time monitor of tumor development. Paramagnetic Mn²⁺ as nonlanthanide metal ion has been widely studied for use in T₁-MRI CAs, but unfortunately, Mn²⁺ can be oxidized by H₂O₂ in tumor to nonparamagnetic Mn⁴⁺ via a Fenton-like reaction. The concurrent loss of paramagnetism and production of toxic hydroxyl radical (OH) go against the basic requirment of CAs, thus restricting the further development of Mn²⁺-based CAs. Based on the different standard potential of W⁶⁺/W⁵⁺ (~0.26 V) and Mn⁴⁺/Mn²⁺ (~1.2 V), a "cathodic protection" strategy was exploited in Mn²⁺-doped Na_xWO₃ nanorods (Na_xMnWO₃), with W⁵⁺ as the sacrificial anode and Mn²⁺ as the protected cathode, to protect Mn²⁺ from oxidation in tumor for stable MR contrast performance, as well as repress its Fenton-like reaction activity for good biosafety. Moreover, the tungsten bronze crystal structure endows Na_xMnWO₃ with excellent near-infrared (NIR)-photothermal properties for effective tumor hyperthermia, without effect from the changed oxidation state of W. This "cathodic protection" strategy offers a new method for the development of reliable and hypotoxic biomaterials for stable imaging and therapeutic applications in clinic.

Keywords: Cathodic protection; MRI contrast agent; Na(x)MnWO(3) nanorod; Photoacoustic imaging; Photothermal therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Electrodes
Humans
Hydrogen Peroxide
Hyperthermia, Induced*
Magnetic Resonance Imaging
Nanotubes*
Neoplasms*
Phototherapy
Photothermal Therapy

Substances

Hydrogen Peroxide