Gender difference in colorectal cancer indicators for exercise interventions: the National Health Insurance Sharing Service-Derived Big Data Analysis

We aimed to examine various characterized features and effects of gender-associated different parameters including exercise on the prevalence of colorectal cancer by using data from the National Health Insurance Sharing Service Database (NHISS DB). Data from NHISS were collected on Koreans aged from 40 to 85 years and were subjected to thematic analysis. The colorectal cancer codes (C19, C20, D011, and D012) from Korean Standard Classification of Disease and Causes of Death selected a target study group, and t-test and logistic regression were used. As results, the age was higher for men who had colorectal cancer than the noncancer group; however, high and low blood pressure, hemoglobin, and age had lower values for the cancer group compared to their counterparts in women. Only total cholesterol in men and waist size in women between cancer and noncancer groups were shown to have significant differences. Serum glutamic pyruvic transaminase and alanine aminotransaminase (SGPT_ALT) showed significant differences for both sexes. In exercise-related parameter, the response number 2 (1-2 times/wk, 0.535 for odd ratio) in women and response number 3 (3-4 times/wk, 0.466 for odd ratio) in men were associated with a reduced incidence of colon cancer. There was a difference in parameters in colorectal cancer patients over 40 years old for both sexes, but not in SGPT_ALT. Regular physical activity might be one of strong factors affecting or predicting colorectal cancer incidence.