Construction and application of targeted drug delivery system based on hyaluronic acid and heparin functionalised carbon dots

Colloids Surf B Biointerfaces. 2020 Apr:188:110768. doi: 10.1016/j.colsurfb.2019.110768. Epub 2019 Dec 31.

Abstract

Thrombosis is a main complication of cancer. It can increase the mortality of cancer patients. Therefore, the anticoagulant heparin (Hep) as an adjuvant therapy was introduced to the drug delivery system based on doxorubicin hydrochloride (DOX)-carbon dots (CDs)-Hyaluronic acid (HA), which obviously enhanced the blood compatibility of the system. Drug release process of the CDs-HA-Hep/DOX system was dual-responsive by HA and pH value. Results of in vitro MTT and scratch tests demonstrated that the drug delivery system could targetedly inhibit growth and migration of cancerous cells. In addition, the system allows visual tracking of the drug based on fluorescence of CDs.

Keywords: Cell migration; Cytotoxicity; Drug tracking; Heparinized carbon dots; Targeted drug delivery system.

MeSH terms

  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology*
  • Carbon / chemistry*
  • Cell Movement / drug effects
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology*
  • Drug Delivery Systems*
  • Drug Liberation
  • Drug Screening Assays, Antitumor
  • Heparin / chemistry*
  • Humans
  • Hyaluronic Acid / chemistry*
  • Particle Size
  • Quantum Dots / chemistry*
  • Surface Properties
  • Tumor Cells, Cultured

Substances

  • Antibiotics, Antineoplastic
  • Carbon
  • Doxorubicin
  • Hyaluronic Acid
  • Heparin