The chronic wound in legs due to vascular abnormalities occurs in 1% to 2% of the adult population. The current treatments are unsatisfactory, and new approaches should be studied. We report in this article a case of a 52-year-old man with a chronic venous wound at the tibia, which has been conventionally treated for nine years. With six weeks of treatment with the autologous fibrin membrane, we were able to identify scar tissue and vascularization, which are characteristic of a healing process.