May the (Mechanical) Force Be with AT2

Julio Sainz de Aja; Carla F Kim

doi:10.1016/j.cell.2019.12.020

May the (Mechanical) Force Be with AT2

Cell. 2020 Jan 9;180(1):20-22. doi: 10.1016/j.cell.2019.12.020.

Authors

Julio Sainz de Aja¹, Carla F Kim²

Affiliations

¹ Stem Cell Program, Division of Hematology/Oncology and Division of Respiratory Disease, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
² Stem Cell Program, Division of Hematology/Oncology and Division of Respiratory Disease, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: [email protected].

Abstract

Idiopathic pulmonary fibrosis is a fatal disease involving destruction of the lung alveolar structure. In this issue of Cell, Wu et al. (2020) show that impaired alveolar (AT2) stem cells produce mechanical tension that leads to spatially regulated fibrosis, initiating a new chapter in understanding what underlies the periphery to center progression of this lung disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Alveolar Epithelial Cells*
Humans
Pulmonary Alveoli
Pulmonary Fibrosis*
Stem Cells
Stress, Mechanical

Abstract

Publication types

MeSH terms

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