Partners in Crime: Clandestine Operations among RAS-RAF Accomplices in Promoting Tumorigenesis

Avinashnarayan Venkatanarayan; Shiva Malek

doi:10.1016/j.molcel.2019.11.020

Partners in Crime: Clandestine Operations among RAS-RAF Accomplices in Promoting Tumorigenesis

Mol Cell. 2019 Dec 19;76(6):853-855. doi: 10.1016/j.molcel.2019.11.020.

Authors

Avinashnarayan Venkatanarayan¹, Shiva Malek²

Affiliations

¹ Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
² Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: [email protected].

PMID: 31951530
DOI: 10.1016/j.molcel.2019.11.020

Abstract

In this issue of Molecular Cell, Terrell et al. (2019) characterize the interactions of RAS-RAF complexes in live cells. Using bioluminescence resonance energy transfer (BRET) technology, they show that individual RAF family members exhibit distinct binding affinities to each RAS family protein, with CRAF exhibiting high binding affinities for all RAS proteins and BRAF exhibiting increased binding affinity for KRAS.

Publication types

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MeSH terms

Carcinogenesis
Crime
Genes, ras*
Humans
Proto-Oncogene Proteins B-raf / genetics*
ras Proteins

Substances

Proto-Oncogene Proteins B-raf
ras Proteins