Emerging from the Shadow of Hemagglutinin: Neuraminidase Is an Important Target for Influenza Vaccination

Florian Krammer; Lei Li; Patrick C Wilson

doi:10.1016/j.chom.2019.11.006

Emerging from the Shadow of Hemagglutinin: Neuraminidase Is an Important Target for Influenza Vaccination

Cell Host Microbe. 2019 Dec 11;26(6):712-713. doi: 10.1016/j.chom.2019.11.006.

Authors

Florian Krammer¹, Lei Li², Patrick C Wilson³

Affiliations

¹ Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
² Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA.
³ Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA. Electronic address: [email protected].

PMID: 31951584
DOI: 10.1016/j.chom.2019.11.006

Abstract

Gilchuk et al. (2019) and Zhu et al. (2019) provide detailed structural information about epitopes on influenza virus N9 neuraminidase and characterize breadth, potency, mechanism of action, and in vivo protective effects of human antibodies targeting these epitopes. The findings highlight the importance of neuraminidase as a target for improved influenza virus vaccines.

Publication types

Comment

MeSH terms

Antibodies, Viral
Hemagglutinins
Humans
Influenza A Virus, H7N9 Subtype*
Influenza Vaccines*
Influenza, Human*
Neuraminidase
Vaccination

Substances

Antibodies, Viral
Hemagglutinins
Influenza Vaccines
Neuraminidase

Grants and funding

P01 AI097092/AI/NIAID NIH HHS/United States