Vagal sensory neurons drive mucous cell metaplasia

Sébastien Talbot; Benjamin Doyle; Junwei Huang; Jo-Chiao Wang; Maryam Ahmadi; David P Roberson; Ajay Yekkirala; Simmie L Foster; Liam E Browne; Bruce P Bean; Bruce D Levy; Clifford J Woolf

doi:10.1016/j.jaci.2020.01.003

Vagal sensory neurons drive mucous cell metaplasia

J Allergy Clin Immunol. 2020 Jun;145(6):1693-1696.e4. doi: 10.1016/j.jaci.2020.01.003. Epub 2020 Jan 16.

Authors

Affiliations

¹ FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, Mass; Department of Neurobiology, Harvard Medical School, Boston, Mass; Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Québec, Canada. Electronic address: [email protected].
² FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, Mass; Department of Neurobiology, Harvard Medical School, Boston, Mass.
³ Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Québec, Canada.
⁴ FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, Mass; Department of Neurobiology, Harvard Medical School, Boston, Mass; Wolfson Institute for Biomedical Research, University College London, London, United Kingdom.
⁵ Department of Neurobiology, Harvard Medical School, Boston, Mass.
⁶ Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
⁷ FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, Mass; Department of Neurobiology, Harvard Medical School, Boston, Mass. Electronic address: [email protected].

Abstract

Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory response.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Female
Immunity, Innate / physiology
Inflammation / pathology
Lung / pathology
Male
Metaplasia / pathology*
Metaplasia / physiopathology
Mice
Mice, Inbred C57BL
Mucus / physiology*
Sensory Receptor Cells / physiology*
Vagus Nerve / physiology*

Abstract

Publication types

MeSH terms

Grants and funding