Electrospun metformin-loaded polycaprolactone/chitosan nanofibrous membranes as promoting guided bone regeneration membranes: Preparation and characterization of fibers, drug release, and osteogenic activity in vitro

J Biomater Appl. 2020 Apr;34(9):1282-1293. doi: 10.1177/0885328220901807. Epub 2020 Jan 21.
No abstract available

Keywords: Metformin; chitosan; electrospinning; guided bone regeneration membranes; osteogenic activity; polycaprolactone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaline Phosphatase / chemistry
  • Animals
  • Bone Marrow Cells / cytology
  • Bone Regeneration*
  • Cell Proliferation
  • Chitosan / chemistry*
  • Cross-Linking Reagents / chemistry
  • Drug Delivery Systems
  • Drug Liberation*
  • Guided Tissue Regeneration / methods*
  • Membranes, Artificial
  • Metformin / chemistry*
  • Nanofibers / chemistry*
  • Osteogenesis
  • Polyesters / chemistry*
  • Rats
  • Rats, Sprague-Dawley
  • Spectroscopy, Fourier Transform Infrared
  • Stress, Mechanical

Substances

  • Cross-Linking Reagents
  • Membranes, Artificial
  • Polyesters
  • polycaprolactone
  • Chitosan
  • Metformin
  • Alkaline Phosphatase