Melatonin attenuates phosgene-induced acute lung injury via the upregulation Wnt/β-catenin pathway

Lin Zhang; Feng Zhang; Daikun He; Daojian Xu; Zhiyue Zhong; Jie Shen

Melatonin attenuates phosgene-induced acute lung injury via the upregulation Wnt/β-catenin pathway

Int J Clin Exp Pathol. 2017 Nov 1;10(11):11281-11287. eCollection 2017.

Authors

Lin Zhang^{1

2

3}, Feng Zhang^{1

2

3}, Daikun He^{1

2

3}, Daojian Xu^{1

2

3}, Zhiyue Zhong^{1

2

3}, Jie Shen^{1

2

3}

Affiliations

¹ Center of Emergency & Intensive Care Unit, Jinshan Hospital, Fudan University Shanghai 201508, P. R. China.
² Medical Center of Chemical Injury, Jinshan Hospital, Fudan University Shanghai 201508, P. R. China.
³ Medical Research Center for Chemical Injury, Emergency and Critical Care of Fudan University P. R. China.

PMID: 31966482
PMCID: PMC6965881

Abstract

The aim of this study was to assess the therapeutic effect of melatonin in phosgene induced acute lung injury (ALI) and to explore the related mechanisms. A rat model of phosgene induced ALI was established and the severity of the ALI was evaluated by wet/dry (W:D) ratio of lung weight, bronchoalveolar lavage (BAL) fluid cell counts and inflammatory cytokines. The rats were administrated with elatonin (MT), ulinastatin (UTI), p38 inhibitor and NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) alone or in combination. We found that MT in combination with UTI significantly improved the severity of ALI and the activation of Wnt/β-catenin signaling was involved in beneficial effect of MT. MT may be used as a therapeutic adjuvant for phosgene induced ALI.

Keywords: Melatonin; Wnt/β-catenin pathway; acute lung injury; phosgene; ulinastatin.