Fabrication of 3D Electrospun Polycaprolactone Sponge Incorporated with Pt@AuNPs for Biomedical Applications

J Nanosci Nanotechnol. 2020 Jul 1;20(7):3989-3993. doi: 10.1166/jnn.2020.17563.

Abstract

Here, we report the synthesis of three-dimensional (3D) polycaprolactone (PCL) nanofiber incorporated with core-satellite platinum nanoparticles (PtNPs, 2-3 nm) coated gold nanospheres (AuNPs, 30 nm) via the simple lactic acid assisted self-assembly electrospinning technique. The Pt-AuNPs nanoparticle in core-satellite form has been prepared by following solution based methods and characterized with TEM, HR-TEM, UV-Visible, and XRD spectroscopic techniques. The surface morphology and structural analysis of 3D nanofiber scaffolds have been performed with FTIR, TGA, FESEM, and HR-TEM analysis techniques and shown the successful preparation of 3D electrospun fibrous structure composed of Pt-AuNPs loaded PCL (PCL@Pt-AuNPs) as a potential biomaterial for bone tissue engineering applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gold*
  • Metal Nanoparticles*
  • Platinum
  • Polyesters
  • Tissue Engineering
  • Tissue Scaffolds

Substances

  • Polyesters
  • polycaprolactone
  • Platinum
  • Gold