A Single Transcription Factor Drives Toxoplasma gondii Differentiation

Joshua A Kochanowsky; Anita A Koshy

doi:10.1016/j.cell.2019.12.038

A Single Transcription Factor Drives Toxoplasma gondii Differentiation

Cell. 2020 Jan 23;180(2):216-218. doi: 10.1016/j.cell.2019.12.038.

Authors

Joshua A Kochanowsky¹, Anita A Koshy²

Affiliations

¹ Department of Immunobiology, University of Arizona, Tucson, Arizona, USA.
² Department of Immunobiology, University of Arizona, Tucson, Arizona, USA; Department of Neurology, University of Arizona, Tucson, Arizona, USA; Bio5 Institute, University of Arizona, Tucson, Arizona, USA. Electronic address: [email protected].

PMID: 31978340
DOI: 10.1016/j.cell.2019.12.038

Abstract

Microbes that cause persistent infections (e.g., herpes viruses) do so by switching from fast-growing lytic states to slow-growing latent states. Waldman et al. have identified a single transcription factor that governs the switch between the lytic and latent forms of Toxoplasma gondii, a parasite that causes a persistent brain infection.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Brain
Cell Differentiation
Gene Expression Regulation
Toxoplasma*
Transcription Factors

Substances

Transcription Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding