Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery

Abigail R Hanby; Nikolaj S Troelsen; Thomas J Osberger; Sarah L Kidd; Kim T Mortensen; David R Spring

doi:10.1039/c9cc09796a

Fsp³-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery

Chem Commun (Camb). 2020 Feb 20;56(15):2280-2283. doi: 10.1039/c9cc09796a.

Authors

Abigail R Hanby¹, Nikolaj S Troelsen², Thomas J Osberger³, Sarah L Kidd⁴, Kim T Mortensen¹, David R Spring¹

Affiliations

¹ Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge, UK. [email protected].
² Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge, UK. [email protected] and Center for Nanomedicine and Theranostics, Department of Chemistry, Technical University of Denmark (DTU), Denmark.
³ Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge, UK. [email protected] and Department of Chemistry, California State Polytechnic University, Pomona, USA.
⁴ Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge, UK. [email protected] and School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, UK.

PMID: 31984987
DOI: 10.1039/c9cc09796a

Abstract

Herein, we describe the natural product inspired synthesis of 38 complex small molecules based upon 20 unique frameworks suitable for fragment-based screening. Utilising an efficient strategy, two key building block diastereomers were harnessed to generate novel, three-dimensional fragments which each possess numerous synthetically accessible fragment growth positions.

MeSH terms

Biological Products / chemical synthesis
Biological Products / chemistry*
Drug Discovery*
Molecular Structure
Small Molecule Libraries / chemical synthesis
Small Molecule Libraries / chemistry*

Substances

Biological Products
Small Molecule Libraries