Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira

Clin Infect Dis. 2020 Nov 5;71(8):1990-1993. doi: 10.1093/cid/ciaa082.

Abstract

Mansonella ozzardi and Mansonella perstans infections both cause mansonellosis but are usually treated differently. Using a real-time polymerase chain reaction assay and deep sequencing, we reveal the presence of mansonellosis coinfections that were undetectable by standard diagnostic methods. Our results confirm mansonellosis coinfections and have important implications for the disease's treatment and diagnosis.

Keywords: Mansonella ozzardi; Mansonella perstans; Brazil; coinfections; mansonellosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brazil / epidemiology
  • Coinfection* / diagnosis
  • Coinfection* / epidemiology
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Mansonella
  • Mansonelliasis*