Urinary Norepinephrine Is a Metabolic Determinant of 24-Hour Energy Expenditure and Sleeping Metabolic Rate in Adult Humans

J Clin Endocrinol Metab. 2020 Apr 1;105(4):1145-1156. doi: 10.1210/clinem/dgaa047.

Abstract

Background: Interindividual variability in 24-hour energy expenditure (24EE) during energy-balance conditions is mainly determined by differences in body composition and demographic factors. Previous studies suggested that 24EE might also be influenced by sympathetic nervous system activity via catecholamine (norepinephrine, epinephrine) secretion. Therefore, we analyzed the association between catecholamines and energy expenditure in 202 individuals from a heterogeneous population of mixed ethnicities.

Methods: Participants (n = 202, 33% female, 14% black, 32% white, 41% Native American, 11% Hispanic, age: 36.9 ± 10.3 y [mean ± SD], percentage body fat: 30.3 ± 9.4) resided in a whole-room calorimeter over 24 hours during carefully controlled energy-balance conditions to measure 24EE and its components: sleeping metabolic rate (SMR), awake-fed thermogenesis (AFT), and spontaneous physical activity (SPA). Urine samples were collected, and 24-h urinary epinephrine and norepinephrine excretion rates were assessed by high-performance liquid chromatography.

Results: Both catecholamines were associated with 24EE and SMR (norepinephrine: +27 and +19 kcal/d per 10 μg/24h; epinephrine: +18 and +10 kcal/d per 1 μg/24h) in separate analyses after adjustment for age, sex, ethnicity, fat mass, fat-free mass, calorimeter room, temperature, and physical activity. In a multivariate model including both norepinephrine and epinephrine, only norepinephrine was independently associated with both 24EE and SMR (both P < .008), whereas epinephrine became insignificant. Neither epinephrine nor norepinephrine were associated with adjusted AFT (both P = .37) but epinephrine was associated with adjusted SPA (+0.5% per 1 μg/24h).

Conclusions: Our data provide compelling evidence that sympathetic nervous system activity, mediated via norepinephrine, is a determinant of human energy expenditure during nonstressed, eucaloric conditions.

Trial registration: ClinicalTrials.gov NCT00856609 NCT00523627 NCT00687115 NCT00342732.

Keywords: catecholamines; energy expenditure; epinephrine; norepinephrine; obesity; sympathetic nervous system.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Basal Metabolism
  • Biomarkers / urine*
  • Body Composition
  • Cross-Sectional Studies
  • Energy Metabolism*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Norepinephrine / urine*
  • Prognosis
  • Sleep / physiology*
  • Thermogenesis*
  • Young Adult

Substances

  • Biomarkers
  • Norepinephrine

Associated data

  • ClinicalTrials.gov/NCT00856609
  • ClinicalTrials.gov/NCT00523627
  • ClinicalTrials.gov/NCT00687115
  • ClinicalTrials.gov/NCT00342732