HAVCR2 mutations are associated with severe hemophagocytic syndrome in subcutaneous panniculitis-like T-cell lymphoma

Gabrielle Sonigo; Maxime Battistella; Marie Beylot-Barry; Saskia Ingen-Housz-Oro; Nathalie Franck; Stéphane Barete; Serge Boulinguez; Olivier Dereure; Nathalie Bonnet; Gérard Socié; Pauline Brice; Olivia Boccara; Christine Bodemer; Henri Adamski; Michel D'Incan; Nicolas Ortonne; Sylvie Fraitag; Florence Brunet-Possenti; Stephane Dalle; Felipe Suarez; Ambroise Marçais; François Skowron; Dima Haidar; Eve Maubec; Gerome Bohelay; Liliane Laroche; Antoine Mahé; Elodie Birckel; Jean-David Bouaziz; Isabelle Brocheriou; Romain Dubois; Sarah Faiz; Jehane Fadlallah; Caroline Ram-Wolff; Agnes Carlotti; Guido Bens; Brigitte Balme; Beatrice Vergier; Sara Laurent-Roussel; Lydia Deschamps; Olivier Carpentier; Philippe Moguelet; Genevieve Herve; François Comoz; François Le Gall; Guy Leverger; Antoine Finon; Olivier Augereau; Claire Bléchet; Remy Kerdraon; Laurence Lamant; Emilie Tournier; Frédéric Franck; Valérie Costes-Martineau; Vanessa Szablewski; Sebastien Taix; Isabelle Beschet; Frédéric Guerin; Fernando E Sepulveda; Martine Bagot; Genevieve de Saint Basile; David Michonneau; Adele de Masson

doi:10.1182/blood.2019003811

HAVCR2 mutations are associated with severe hemophagocytic syndrome in subcutaneous panniculitis-like T-cell lymphoma

Blood. 2020 Mar 26;135(13):1058-1061. doi: 10.1182/blood.2019003811.

Authors

Gabrielle Sonigo¹, Maxime Battistella², Marie Beylot-Barry³, Saskia Ingen-Housz-Oro⁴, Nathalie Franck⁵, Stéphane Barete⁶, Serge Boulinguez⁷, Olivier Dereure⁸, Nathalie Bonnet⁹, Gérard Socié¹⁰, Pauline Brice¹¹, Olivia Boccara¹², Christine Bodemer¹², Henri Adamski¹³, Michel D'Incan¹⁴, Nicolas Ortonne¹⁵, Sylvie Fraitag¹⁶, Florence Brunet-Possenti¹⁷, Stephane Dalle¹⁸, Felipe Suarez¹⁹, Ambroise Marçais¹⁹, François Skowron²⁰, Dima Haidar²¹, Eve Maubec²², Gerome Bohelay²², Liliane Laroche²², Antoine Mahé²³, Elodie Birckel²³, Jean-David Bouaziz¹, Isabelle Brocheriou²⁴, Romain Dubois²⁵, Sarah Faiz²⁶, Jehane Fadlallah²⁷, Caroline Ram-Wolff¹, Agnes Carlotti²⁸, Guido Bens²⁹, Brigitte Balme³⁰, Beatrice Vergier³¹, Sara Laurent-Roussel³², Lydia Deschamps³³, Olivier Carpentier²⁶, Philippe Moguelet²⁴, Genevieve Herve²⁴, François Comoz³⁴, François Le Gall³⁵, Guy Leverger³⁶, Antoine Finon²⁹, Olivier Augereau³¹, Claire Bléchet³⁷, Remy Kerdraon³⁷, Laurence Lamant³⁸, Emilie Tournier³⁸, Frédéric Franck³⁹, Valérie Costes-Martineau⁴⁰, Vanessa Szablewski⁴⁰, Sebastien Taix⁴¹, Isabelle Beschet⁴², Frédéric Guerin⁴³, Fernando E Sepulveda⁴³, Martine Bagot¹, Genevieve de Saint Basile⁴³, David Michonneau¹⁰, Adele de Masson¹

Affiliations

¹ Department of Dermatology, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), INSERM U976, Université de Paris, Paris, France.
² Department of Pathology, Hôpital Saint Louis, AP-HP, Paris, France.
³ Department of Dermatology, CHU Bordeaux, INSERM U1053, University of Bordeaux, Bordeaux, France.
⁴ Department of Dermatology, AP-HP, Hôpital Henri-Mondor, Créteil, France.
⁵ Department of Dermatology, Hôpital Cochin, AP-HP, Paris, France.
⁶ Department of Dermatology, Hôpital Pitié Salpêtrière, AP-HP, Paris, France.
⁷ Department of Dermatology, CHU Toulouse, Toulouse, France.
⁸ Department of Dermatology, CHU Montpellier, Montpellier, France.
⁹ Department of Dermatology, Hôpital Nord, Marseille, France.
¹⁰ Hematology and Transplantation Unit and.
¹¹ Hematology and Oncology Unit, Hôpital Saint Louis, AP-HP, Paris, France.
¹² Department of Dermatology, Hôpital Necker, AP-HP, Paris, France.
¹³ Department of Dermatology, CHU Pontchaillou, Rennes, France.
¹⁴ Department of Dermatology, CHU Clermont-Ferrand, Clermont-Ferrand, France.
¹⁵ Department of Pathology, Hôpital Henri-Mondor, AP-HP, Créteil, France.
¹⁶ Department of Pathology, Hôpital Necker, AP-HP, Paris, France.
¹⁷ Department of Dermatology, Hôpital Bichat, AP-HP, Paris, France.
¹⁸ Department of Dermatology, CH Lyon Sud, Lyon, France.
¹⁹ Department of Adult Hematology, Hôpital Necker, AP-HP, Paris, France.
²⁰ Department of Dermatology, CH de Valence, Valence, France.
²¹ Department of Dermatology, CHU Côte de Nacre, Caen, France.
²² Deparment of Dermatology, Hôpital Avicenne, AP-HP, Bobigny, France.
²³ Department of Dermatology, Hôpital Louis Pasteur, Colmar, France.
²⁴ Department of Pathology, Hôpital Pitié Salpétrière, AP-HP, Paris, France.
²⁵ Department of Pathology, CHRU de Lille, Lille, France.
²⁶ Department of Dermatology, CHRU de Lille, Lille, France.
²⁷ Department of Clinical Immunology, Hôpital Saint Louis, AP-HP, Paris, France.
²⁸ Department of Pathology, Hôpital Cochin, AP-HP, Paris, France.
²⁹ Department of Dermatology, CHR d'Orléans, Orléans, France.
³⁰ Department of Pathology, CH Lyon Sud, Lyon, France.
³¹ Department of Pathology, CHU Bordeaux, INSERM U1053, University of Bordeaux, Bordeaux, France.
³² Department of Pathology, Hôpital Avicenne, AP-HP, Bobigny, France.
³³ Department of Pathology, Hôpital Bichat, AP-HP, Paris, France.
³⁴ Department of Pathology, CHU Côte de Nacre, Caen, France.
³⁵ Department of Pathology, CHU Pontchaillou, Rennes, France.
³⁶ Department of Pediatric Hematology, Hôpital Trousseau, AP-HP, Paris, France.
³⁷ Department of Pathology, CHR d'Orléans, Orléans, France.
³⁸ Department of Pathology, CHU Toulouse, Toulouse, France.
³⁹ Department of Pathology, CHU Clermont-Ferrand, Clermont-Ferrand, France.
⁴⁰ Department of Pathology, CHU Montpellier, Montpellier, France.
⁴¹ Department of Pathology, Institut Paoli-Calmettes, Marseille, France.
⁴² Department of Pathology, CH de Valence, Valence, France; and.
⁴³ Laboratory of Normal and Pathological Homeostasis of the Immune System, INSERM U1163, Institut Imagine, Université de Paris, Paris, France.

PMID: 32005988
DOI: 10.1182/blood.2019003811

No abstract available

Publication types

Letter

MeSH terms

Biomarkers
Female
Genetic Association Studies
Genetic Predisposition to Disease*
Hepatitis A Virus Cellular Receptor 2 / genetics*
Humans
Lymphohistiocytosis, Hemophagocytic / diagnosis*
Lymphohistiocytosis, Hemophagocytic / genetics*
Lymphoma, T-Cell / diagnosis*
Lymphoma, T-Cell / genetics*
Male
Mutation*
Panniculitis / diagnosis*
Panniculitis / genetics*

Substances

Biomarkers
HAVCR2 protein, human
Hepatitis A Virus Cellular Receptor 2

Supplementary concepts

Subcutaneous panniculitis-like T-cell lymphoma