[Chemotherapy and young women in breast cancer: what management?]

Bull Cancer. 2019 Dec;106(12S1):S19-S23. doi: 10.1016/S0007-4551(20)30043-6.
[Article in French]

Abstract

Breast cancer in young women requires special vigilance because of the unique condition and complex management that is involved. The indication for chemotherapy should not be based on age alone but in association with the biological characteristics of the tumour. In addition, age is not considered as demonstrated predictor of chemosensitivity. The choice of adjuvant or neoadjuvant chemotherapy should be guided by the histological type of the tumour, the stage of the tumour and the patient's comorbidities. In this subgroup of patients, the recommendations for the use of molecular signatures follow those of the general population. This manuscript summarizes the main data and recommendations on the management of breast cancer in young women in term of chemotherapy.

Keywords: Breast cancer; Cancer du sein; Chemotherapy; Chimiothérapie; Femme jeune; Young women.

Publication types

  • Review

MeSH terms

  • Adult
  • Age Factors*
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Breast Neoplasms / chemistry
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Chemotherapy, Adjuvant
  • Clinical Trials as Topic
  • Female
  • Fertility Preservation
  • Humans
  • Neoadjuvant Therapy*
  • Premenopause
  • Prospective Studies
  • Retrospective Studies
  • Triple Negative Breast Neoplasms / chemistry
  • Triple Negative Breast Neoplasms / drug therapy
  • Triple Negative Breast Neoplasms / genetics

Substances

  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal