Invasive Tracheobronchial Aspergillosis with Bronchial Ulcers Complicated by Nontuberculous Mycobacterial Disease

Intern Med. 2020 May 1;59(9):1189-1194. doi: 10.2169/internalmedicine.3827-19. Epub 2020 Feb 1.

Abstract

Invasive tracheobronchial aspergillosis (ITBA) complicated by nontuberculous mycobacteria (NTM) is rare. An 88-year-old man was admitted for hemoptysis. Bronchoscopy revealed bronchial ulcers, and a tissue biopsy showed Aspergillus fumigatus. He was diagnosed with ITBA, which improved with voriconazole. During treatment, infiltrative shadows appeared in his lungs, and bronchoscopy was performed once again. A non-necrotic epithelioid granuloma and Mycobacterium intracellulare were detected in the biopsy specimen. He was diagnosed with NTM disease. It is important to note that tracheobronchial ulcers may cause hemoptysis and to identify the etiology and treat it appropriately when multiple bacteria are found.

Keywords: bronchial ulcer; hemoptysis; invasive tracheobronchial aspergillosis; non-tuberculous mycobacteria.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Antifungal Agents / therapeutic use
  • Aspergillosis / complications
  • Aspergillosis / diagnosis*
  • Aspergillosis / drug therapy
  • Aspergillus fumigatus / isolation & purification*
  • Bronchial Diseases / complications
  • Bronchial Diseases / diagnosis*
  • Bronchial Diseases / drug therapy
  • Bronchoscopy
  • Diagnosis, Differential
  • Humans
  • Male
  • Mycobacterium Infections, Nontuberculous / complications
  • Mycobacterium Infections, Nontuberculous / diagnosis*
  • Mycobacterium Infections, Nontuberculous / drug therapy
  • Mycobacterium avium Complex / isolation & purification*
  • Ulcer / complications
  • Ulcer / diagnosis*
  • Ulcer / drug therapy
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Voriconazole