Late-Stage Modification of Tertiary Phosphines via Ruthenium(II)-Catalyzed C-H Alkylation

Org Lett. 2020 Feb 21;22(4):1331-1335. doi: 10.1021/acs.orglett.9b04590. Epub 2020 Feb 3.

Abstract

Ru(II)-catalyzed direct alkylation of tertiary phosphines via hydroarylation of activated olefins promoted by mono-N-protected amino acid (MPAA) was achieved. This protocol provides a straightforward access to a large library of Buchwald-type bulky alkylated monophosphines from commercially available biaryl phosphine. Moreover, two ruthenacycle intermediates of tertiary phosphines via C-H bond cleavage were isolated to illustrate the mechanism of P(III)-directed C-H activation.

Publication types

  • Research Support, Non-U.S. Gov't