3D-Printed Gastric Resident Electronics

Yong Lin Kong; Xingyu Zou; Caitlin A McCandler; Ameya R Kirtane; Shen Ning; Jianlin Zhou; Abubakar Abid; Mousa Jafari; Jaimie Rogner; Daniel Minahan; Joy E Collins; Shane McDonnell; Cody Cleveland; Taylor Bensel; Siid Tamang; Graham Arrick; Alla Gimbel; Tiffany Hua; Udayan Ghosh; Vance Soares; Nancy Wang; Aniket Wahane; Alison Hayward; Shiyi Zhang; Brian R Smith; Robert Langer; Giovanni Traverso

doi:10.1002/admt.201800490

3D-Printed Gastric Resident Electronics

Adv Mater Technol. 2019;4(3):1800490. doi: 10.1002/admt.201800490. Epub 2018 Dec 13.

Authors

Yong Lin Kong¹, Xingyu Zou^{1

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6}, Caitlin A McCandler^{1

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6}, Ameya R Kirtane^{1

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3

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6}, Shen Ning², Jianlin Zhou^{1

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3

4

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6}, Abubakar Abid^{1

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3

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6}, Mousa Jafari^{1

2

3

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6}, Jaimie Rogner^{1

2

3

4

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6}, Daniel Minahan^{1

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3

4

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6}, Joy E Collins^{1

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6}, Shane McDonnell^{1

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6}, Cody Cleveland^{1

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6}, Taylor Bensel^{1

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3

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6}, Siid Tamang^{1

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6}, Graham Arrick^{1

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6}, Alla Gimbel^{1

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6}, Tiffany Hua^{1

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6}, Udayan Ghosh¹, Vance Soares^{1

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6}, Nancy Wang^{1

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6}, Aniket Wahane^{1

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3

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6}, Alison Hayward^{1

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6}, Shiyi Zhang^{1

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6}, Brian R Smith^{1

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6}, Robert Langer³, Giovanni Traverso^{4

5}

Affiliations

¹ Department of Mechanical Engineering University of Utah Salt Lake City, UT 84112, USA.
² Boston University School of Medicine 72 E Concord St, Boston, MA 02118, USA.
³ Charles Stark Draper Laboratory Cambridge, MA 02139, USA.
⁴ Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge, MA 02139, USA.
⁵ Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School Boston, MA 02115, USA.
⁶ Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge, MA 02139, USA.

Abstract

Long-term implantation of biomedical electronics into the human body enables advanced diagnostic and therapeutic functionalities. However, most long-term resident electronics devices require invasive procedures for implantation as well as a specialized receiver for communication. Here, a gastric resident electronic (GRE) system that leverages the anatomical space offered by the gastric environment to enable residence of an orally delivered platform of such devices within the human body is presented. The GRE is capable of directly interfacing with portable consumer personal electronics through Bluetooth, a widely adopted wireless protocol. In contrast to the passive day-long gastric residence achieved with prior ingestible electronics, advancement in multimaterial prototyping enables the GRE to reside in the hostile gastric environment for a maximum of 36 d and maintain ≈15 d of wireless electronics communications as evidenced by the studies in a porcine model. Indeed, the synergistic integration of reconfigurable gastric-residence structure, drug release modules, and wireless electronics could ultimately enable the next-generation remote diagnostic and automated therapeutic strategies.

Keywords: 3D printing; biomedical devices; gastric resident devices; gastric resident electronics; ingestible electronics.