Data on genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains

Daniela T Fuller; Andrew T Grainger; Ani Manichaikul; Weibin Shi

doi:10.1016/j.dib.2020.105165

Data on genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains

Data Brief. 2020 Jan 23:29:105165. doi: 10.1016/j.dib.2020.105165. eCollection 2020 Apr.

Authors

Daniela T Fuller¹, Andrew T Grainger², Ani Manichaikul^{2

3}, Weibin Shi^{1

2}

Affiliations

¹ Department of Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, USA.
² Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
³ Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.

Abstract

The data presented here are related to the research article, entitled Genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains, published in Atherosclerosis 2019 Dec 3;293:1-10 (D. Fuller, A.T. Grainger, A. Manichaikul, W. Shi). The supporting materials include original genotypic and phenotypic data obtained from 266 female F2 mice derived from an intercross between C57BL/6 (B6) and BALB/cJ (BALB) Apoe^-/- mice. F2 mice were fed 12 weeks of Western diet, starting at 6 weeks of age. Plasma levels of HDL, LDL cholesterol, triglycerides, glucose and malondialdehyde (MDA) and atherosclerosis in the aortic root and the left carotid artery were measured. 127 microsatellite markers across the entire genome were genotyped. The data is provided in the format ready for QTL analysis with J/qtl and MapManager QTX.

Keywords: Atherosclerosis; Cardiometabolic trait; Genetic linkage; Mouse; Oxidative stress.

Grants and funding

R01 DK116768/DK/NIDDK NIH HHS/United States