Abstract
The enzymatic-assisted signal amplification of DNA sensors is rarely applied in living cells due to the difficulties in protein delivery. In this study, we have proposed a biomineralization-based DNA nanoprobe to transport nucleases and DNA sensors for enzyme-assisted imaging of microRNA in living cells.
MeSH terms
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Biomineralization*
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DNA / metabolism*
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DNA Probes / chemistry*
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Exodeoxyribonucleases / metabolism*
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Humans
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Metal-Organic Frameworks / chemistry
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MicroRNAs / metabolism
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Nanoparticles / chemistry*
Substances
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DNA Probes
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Metal-Organic Frameworks
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MicroRNAs
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DNA
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Exodeoxyribonucleases
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exodeoxyribonuclease III