Secondary histiocytic sarcoma with BRAF^V600E mutation after T-cell acute lymphoblastic leukemia in a very young child with dramatic response to dabrafenib and trametinib

MeSH terms

• Amino Acid Substitution
• Histiocytic Sarcoma* / drug therapy
• Histiocytic Sarcoma* / genetics
• Histiocytic Sarcoma* / metabolism
• Histiocytic Sarcoma* / pathology
• Humans
• Imidazoles / administration & dosage*
• Infant
• Male
• Mutation, Missense*
• Neoplasms, Second Primary* / drug therapy
• Neoplasms, Second Primary* / genetics
• Neoplasms, Second Primary* / metabolism
• Neoplasms, Second Primary* / pathology
• Oximes / administration & dosage*
• Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / drug therapy
• Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / genetics
• Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / metabolism
• Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / pathology
• Proto-Oncogene Proteins B-raf* / genetics
• Proto-Oncogene Proteins B-raf* / metabolism
• Pyridones / administration & dosage*
• Pyrimidinones / administration & dosage*