Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate

Yu Toyoda; Tappei Takada; Hiroki Saito; Hiroshi Hirata; Ami Ota-Kontani; Naoyuki Kobayashi; Youichi Tsuchiya; Hiroshi Suzuki

doi:10.1038/s41538-020-0063-7

Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate

NPJ Sci Food. 2020 Feb 5:4:3. doi: 10.1038/s41538-020-0063-7. eCollection 2020.

Authors

Affiliations

¹ 1Department of Pharmacy, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan.
² 2Frontier Laboratories for Value Creation, SAPPORO HOLDINGS LTD., 10 Okatome, Yaizu, Shizuoka, 425-0013 Japan.

^# Contributed equally.

Abstract

As hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased attention. Here, we examined the inhibitory activities of seven Citrus flavonoids against URAT1, a renal transporter involved in urate re-uptake from urine. We found that naringenin and nobiletin strongly inhibited URAT1, and may therefore serve as an anti-hyperuricemic food ingredient that can reduce the risk of urate-related diseases.

Keywords: Biochemistry; Nutrition.