Disentangling outbreaks using whole-genome sequencing: concurrent multistate outbreaks of Salmonella Kottbus in Germany, 2017

Epidemiol Infect. 2020 Feb 13:148:e51. doi: 10.1017/S0950268820000394.

Abstract

In June 2017, an outbreak of Salmonella Kottbus infection was suspected in Germany. We investigated the outbreak with whole-genome sequencing (WGS) and a case-control study. Forty-six isolates from 69 cases were subtyped. Three WGS clusters were identified: cluster 1 (n = 36), cluster 2 (n = 5) and cluster 3 (n = 3). Compared to controls, cluster 1 cases more frequently consumed raw smoked ham (odds ratio (OR) 10, 95% confidence interval (CI) 1.2-88) bought at supermarket chain X (OR 36, 95% CI 4-356; 9/10 consumed ham Y). All four cluster 2 cases interviewed had consumed quail eggs. Timely WGS was invaluable in distinguishing concurrent outbreaks of a rare Salmonella serotype.

Keywords: Food-borne infections; Germany; molecular epidemiology; outbreaks; salmonellosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Cluster Analysis
  • Disease Outbreaks*
  • Feeding Behavior
  • Female
  • Foodborne Diseases / epidemiology*
  • Foodborne Diseases / microbiology
  • Germany / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Molecular Epidemiology / methods*
  • Molecular Typing / methods*
  • Salmonella Infections / epidemiology*
  • Salmonella Infections / microbiology
  • Salmonella enterica / classification*
  • Salmonella enterica / genetics
  • Salmonella enterica / isolation & purification
  • Whole Genome Sequencing / methods*