Bedaquiline resistance in drug-resistant tuberculosis HIV co-infected patients

Eur Respir J. 2020 Jun 4;55(6):1902383. doi: 10.1183/13993003.02383-2019. Print 2020 Jun.

Abstract

Genetic mutations linked to bedaquiline resistance were found before starting treatment and acquired during treatment in patients with drug-resistant TB and HIV in KwaZulu-Natal, South Africa. Routine bedaquiline resistance testing needs to be accelerated. http://bit.ly/2vnL4VY

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Coinfection* / drug therapy
  • Diarylquinolines / therapeutic use
  • HIV Infections* / complications
  • HIV Infections* / drug therapy
  • Humans
  • Mycobacterium tuberculosis*
  • Tuberculosis, Multidrug-Resistant* / complications
  • Tuberculosis, Multidrug-Resistant* / drug therapy

Substances

  • Antitubercular Agents
  • Diarylquinolines
  • bedaquiline