Randomized phase 1 study of sequential ("primed") vs. concurrent decitabine in combination with cladribine, cytarabine, G-CSF, and mitoxantrone (CLAG-M) in adults with newly diagnosed or relapsed/refractory acute myeloid leukemia (AML) or other high-grade myeloid neoplasm

Leuk Lymphoma. 2020 Jul;61(7):1728-1731. doi: 10.1080/10428194.2020.1728754. Epub 2020 Feb 20.
No abstract available

Publication types

  • Clinical Trial, Phase I
  • Letter
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cladribine* / therapeutic use
  • Cytarabine* / therapeutic use
  • Decitabine* / therapeutic use
  • Granulocyte Colony-Stimulating Factor* / therapeutic use
  • Humans
  • Leukemia, Myeloid, Acute* / diagnosis
  • Leukemia, Myeloid, Acute* / drug therapy
  • Mitoxantrone* / therapeutic use
  • Treatment Outcome

Substances

  • Cytarabine
  • Granulocyte Colony-Stimulating Factor
  • Cladribine
  • Decitabine
  • Mitoxantrone

Associated data

  • ClinicalTrials.gov/NCT02921061